Spermatid differentiation

Across TCGA patient cohorts, RNA activity of the Spermatid differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BBS2, WDR19, and WDR54, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermatid differentiation activity versus BBS2 in UCEC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BBS2 →	+0.523	+0.057	<.001	<.001	3	7
UCEC	WDR19 →	+0.422	+0.059	<.001	<.001	3	7
UCEC	WDR54 →	+0.573	+0.061	<.001	<.001	3	7
UCEC	IFT74 →	+0.405	+0.049	<.001	<.001	3	7
UCEC	IFT46 →	+0.414	+0.049	<.001	<.001	3	7
BRCA	BBS4 →	+0.497	+0.019	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048515 vs BBS2 — UCEC

Explore this scatter interactively →