Spermatid differentiation

Across TCGA cell cohorts, RNA activity of the Spermatid differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX11A, EEF2, and CHAC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spermatid differentiation activity versus PEX11A in OVARY (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PEX11A →	-0.877	-0.194	.002	.003	3	4
BLOOD_Leukemia	EEF2 →	-0.592	-0.714	.009	.005	2	5
LIVER	CHAC1 →	+1.691	+0.188	.002	.007	3	3
LIVER	MORF4L1 →	+0.855	+0.249	.002	.006	3	3
LIVER	PTRH1 →	-1.561	-0.246	<.001	.007	3	3
LIVER	LY6G5C →	+0.770	+0.190	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048515 vs PEX11A — OVARY

Explore this scatter interactively →