Rhythmic process

Across TCGA cell cohorts, RNA activity of the Rhythmic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIN3B, USP37, and ZMYM6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIN3B grouped by Rhythmic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SIN3B →	+0.902	+0.192	<.001	.003	3	5
KIDNEY	USP37 →	+0.491	+0.145	.008	.004	3	5
LUNG_NSCLC_LUSC	ZMYM6 →	+0.596	+0.141	.008	<.001	3	5
URINARY_TRACT	RNASEK →	-0.693	-0.128	.002	.003	3	5
STOMACH	MGA →	+1.084	+0.141	.003	.001	3	5
LUNG_NSCLC_LUSC	MEAF6 →	+0.691	+0.125	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIN3B by Rhythmic process activity — KIDNEY

Explore this box plot interactively →