Rhythmic process

Across TCGA cell cohorts, RNA activity of the Rhythmic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDC, EN2, and OR1S1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HDC grouped by Rhythmic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HDC →	-0.252	-0.227	<.001	<.001	3	4
LUNG_SCLC	EN2 →	+0.313	+0.226	.006	.003	2	5
SKIN	OR1S1 →	-0.211	-0.155	.001	.002	3	4
PANCREAS	RBKS →	-0.190	-0.195	.007	.003	3	4
OVARY	SNRPA →	-0.248	-0.251	<.001	<.001	3	3
BLOOD_Leukemia	PPP2R3C →	-0.330	-0.213	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HDC by Rhythmic process activity — SKIN

Explore this box plot interactively →