Rhythmic process

Across TCGA cell cohorts, RNA activity of the Rhythmic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTP4A1, FAM218A, and LDHA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rhythmic process activity versus PTP4A1 in LIVER (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PTP4A1 →	-1.258	-0.188	.009	.003	3	5
BLOOD_Lymphoma	FAM218A →	+0.662	+0.114	.006	<.001	3	4
BREAST	LDHA →	+0.760	+0.148	.009	.002	3	4
KIDNEY	TMED1 →	-0.634	-0.228	.001	<.001	3	4
BONE	B4GALT4 →	-1.119	-0.168	.005	.009	3	4
BONE	PROB1 →	+1.036	+0.174	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048511 vs PTP4A1 — LIVER

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