Maintenance of animal organ identity

Across TCGA patient cohorts, RNA activity of the Maintenance of animal organ identity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PKP2, PKP2_S251, and PKP2_S329, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of animal organ identity activity versus PKP2 in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PKP2 →	+0.932	+0.082	<.001	<.001	3	8
HNSC	PKP2_S251 →	+1.004	+0.085	<.001	<.001	3	6
BRCA	PKP2_S329 →	+0.547	+0.040	<.001	.006	3	6
LUAD	CNN2 →	-0.344	-0.088	<.001	<.001	3	5
OV	PKP2_S151 →	+0.878	+0.104	<.001	<.001	3	5
PDAC	GFPT2_S244 →	-0.466	-0.052	.002	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048496 vs PKP2 — OV

Explore this scatter interactively →