Maintenance of animal organ identity

Across TCGA cell cohorts, RNA activity of the Maintenance of animal organ identity pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GADD45A, RBBP5, and SAMD8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GADD45A grouped by Maintenance of animal organ identity-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GADD45A →	-0.270	-0.240	.001	.009	3	4
BLOOD_Lymphoma	RBBP5 →	-0.290	-0.137	.002	<.001	3	4
BLOOD_Lymphoma	SAMD8 →	-0.450	-0.129	.002	.002	3	4
LUNG_SCLC	TRIM49C →	+0.249	+0.116	.003	.008	3	4
KIDNEY	PLPP7 →	+0.146	+0.139	.004	.002	3	3
KIDNEY	ARV1 →	+0.178	+0.178	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GADD45A by Maintenance of animal organ identity activity — BONE

Explore this box plot interactively →