Synaptic vesicle transport

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAP1GAP_S484, FAM126B_S321, and VCL_S275, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle transport activity versus RAP1GAP_S484 in BRCA (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAP1GAP_S484 →	+0.852	+0.025	<.001	<.001	3	5
GBM	FAM126B_S321 →	+0.872	+0.061	<.001	<.001	3	5
PDAC	VCL_S275 →	-0.445	-0.021	.009	.003	3	4
LUAD	FASN_T2204 →	-0.639	-0.034	<.001	.001	3	4
UCEC	ACAP3_S544 →	+0.556	+0.139	.004	.001	3	4
CCRCC	ZBTB22_S202 →	+0.604	+0.038	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048489 vs RAP1GAP_S484 — BRCA

Explore this scatter interactively →