Synaptic vesicle transport

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNRC6B, CENPV, and DLGAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle transport activity versus TNRC6B in GBM (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNRC6B →	+0.385	+0.207	.001	.003	3	4
GBM	CENPV →	+0.747	+0.240	<.001	<.001	3	4
GBM	DLGAP1 →	+1.140	+0.306	<.001	<.001	3	4
HNSC	NRXN3 →	+0.811	+0.212	<.001	<.001	3	4
GBM	ATP8A1 →	+1.340	+0.436	<.001	<.001	3	4
GBM	SYNGR1 →	+0.903	+0.298	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048489 vs TNRC6B — GBM

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