Synaptic vesicle transport

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCSAP_S240, FOSL2_S120, and LRRK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle transport activity versus CCSAP_S240 in GBM (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCSAP_S240 →	+0.479	+0.204	<.001	.001	3	4
GBM	FOSL2_S120 →	-0.931	-0.422	<.001	<.001	3	4
OV	LRRK2 →	+1.152	+0.239	<.001	<.001	3	4
BRCA	SLC27A2_T577 →	+1.000	+0.212	<.001	<.001	3	3
OV	CKS1B →	-0.852	-0.189	<.001	<.001	3	3
GBM	CRTAC1 →	+0.452	+0.245	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048489 vs CCSAP_S240 — GBM

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