Synaptic vesicle transport

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle transport pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAXBP1, CTNNB1, and SAE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAXBP1 grouped by Synaptic vesicle transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PAXBP1 →	+0.198	+1.037	<.001	<.001	3	5
LARGE_INTESTINE	CTNNB1 →	-1.303	-0.846	<.001	<.001	3	5
BLOOD_Myeloma	SAE1 →	-0.410	-1.717	.001	<.001	3	4
OVARY	SYNJ1 →	-0.224	-1.197	.001	.001	3	4
CNS	AP3M1 →	-0.230	-0.892	.006	.009	3	4
OVARY	RGL3 →	-0.262	-1.048	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAXBP1 by Synaptic vesicle transport activity — CNS

Explore this box plot interactively →