Synaptic vesicle transport

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A3, TTLL5, and SLC15A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100A3 grouped by Synaptic vesicle transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	S100A3 →	-1.584	-0.891	.001	.006	3	5
KIDNEY	TTLL5 →	-0.969	-1.299	.004	.003	3	4
KIDNEY	SLC15A4 →	+0.980	+1.140	.001	.002	2	4
KIDNEY	PIP5K1A →	-0.789	-1.171	.002	.004	3	3
KIDNEY	LUC7L2 →	-0.595	-0.916	<.001	.004	3	3
KIDNEY	C21orf91 →	-0.566	-1.091	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100A3 by Synaptic vesicle transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →