Synaptic vesicle transport

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1, LMF2, and PLOD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle transport activity versus HNRNPA1 in PANCREAS (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HNRNPA1 →	-0.772	-1.035	.002	.001	3	5
BREAST	LMF2 →	+0.581	+0.578	.003	.005	2	6
BLOOD_Leukemia	PLOD1 →	+0.756	+0.660	.005	.002	3	4
BLOOD_Lymphoma	DUSP18 →	+0.833	+0.931	.001	.001	3	4
SOFT_TISSUE	RPL10A →	-0.811	-1.358	<.001	.002	3	4
LUNG_SCLC	RAPGEF5 →	-1.578	-0.806	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048489 vs HNRNPA1 — PANCREAS

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