Parasympathetic nervous system development

Across TCGA patient cohorts, RNA activity of the Parasympathetic nervous system development pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS1, C1S, and CTHRC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parasympathetic nervous system development activity versus THBS1 in COAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	THBS1 →	+0.916	+0.050	<.001	<.001	3	7
OV	C1S →	+0.661	+0.083	<.001	<.001	3	7
COAD	CTHRC1 →	+1.058	+0.060	<.001	.001	3	7
OV	COL3A1 →	+0.820	+0.093	<.001	<.001	3	7
OV	C8A →	+0.559	+0.065	.003	.005	3	6
COAD	SFRP2 →	+1.327	+0.054	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048486 vs THBS1 — COAD

Explore this scatter interactively →