Parasympathetic nervous system development

Across TCGA patient cohorts, RNA activity of the Parasympathetic nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAI1, NAV2, and CCDC58P5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parasympathetic nervous system development activity versus RAI1 in LUAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAI1 →	+0.375	+0.329	.007	.005	3	3
LUAD	NAV2 →	+0.833	+0.646	<.001	<.001	3	3
LUAD	CCDC58P5 →	+0.448	+0.416	.005	.003	3	3
LSCC	RN7SKP299 →	+0.529	+0.283	<.001	<.001	3	3
UCEC	AIMP1P2 →	-0.388	-0.240	.005	.001	3	3
UCEC	GNB1 →	+0.247	+0.242	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048486 vs RAI1 — LUAD

Explore this scatter interactively →