Parasympathetic nervous system development

Across TCGA cell cohorts, RNA activity of the Parasympathetic nervous system development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP9, SPRR3, and TGFBR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKAP9 grouped by Parasympathetic nervous system development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AKAP9 →	+0.142	+1.033	.002	.004	3	4
BLOOD_Leukemia	SPRR3 →	-0.198	-1.492	.001	<.001	3	4
LUNG_NSCLC_LUSC	TGFBR2 →	-0.133	-0.183	<.001	<.001	3	4
PANCREAS	EDF1 →	+0.208	+0.161	<.001	<.001	3	4
KIDNEY	TREML2 →	+0.172	+0.168	<.001	<.001	3	3
BLOOD_Lymphoma	ANGEL1 →	+0.356	+1.721	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKAP9 by Parasympathetic nervous system development activity — BLOOD_Leukemia

Explore this box plot interactively →