Parasympathetic nervous system development

Across TCGA cell cohorts, RNA activity of the Parasympathetic nervous system development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF81, UBASH3B, and NRG1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF81 grouped by Parasympathetic nervous system development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF81 →	+0.323	+2.309	.009	.001	3	2
OVARY	UBASH3B →	+0.245	+1.644	.001	<.001	3	2
SKIN	NRG1 →	+0.118	+1.925	.008	.001	2	2
SKIN	CES5A →	+0.195	+1.925	<.001	.001	2	2
CNS	PSMB5 →	-0.869	-1.577	.007	<.001	3	1
CNS	DDX6 →	+0.423	+1.560	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF81 by Parasympathetic nervous system development activity — BREAST

Explore this box plot interactively →