Sympathetic nervous system development

Across TCGA patient cohorts, RNA activity of the Sympathetic nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITK, LINC00426, and GRAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sympathetic nervous system development activity versus ITK in BRCA (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITK →	-0.840	-0.508	<.001	<.001	3	5
LSCC	LINC00426 →	-0.518	-0.766	.004	.006	3	5
BRCA	GRAP2 →	-0.595	-0.391	<.001	.003	3	4
BRCA	GZMH →	-1.081	-0.591	<.001	<.001	3	4
BRCA	CORO1A →	-0.949	-0.495	.001	.001	3	4
BRCA	RASAL3 →	-0.904	-0.542	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048485 vs ITK — BRCA

Explore this scatter interactively →