Sympathetic nervous system development

Across TCGA patient cohorts, RNA activity of the Sympathetic nervous system development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NF1_T2565, NF1_S2543, and SKAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sympathetic nervous system development activity versus NF1_T2565 in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NF1_T2565 →	+0.755	+0.458	<.001	<.001	3	4
GBM	NF1_S2543 →	+0.689	+0.498	<.001	<.001	3	4
LSCC	SKAP1 →	-0.439	-1.041	<.001	<.001	3	3
GBM	BIN2 →	-0.534	-0.349	<.001	.002	2	4
BRCA	CD8A →	-0.749	-0.552	.001	<.001	3	3
BRCA	FNBP1 →	-0.384	-0.481	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048485 vs NF1_T2565 — GBM

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