Sympathetic nervous system development

Across TCGA cell cohorts, RNA activity of the Sympathetic nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSH2, ARFGAP2, and ZNF48, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SSH2 grouped by Sympathetic nervous system development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SSH2 →	-0.664	-0.375	<.001	<.001	3	5
BREAST	ARFGAP2 →	+0.674	+0.458	.003	.006	3	4
BREAST	ZNF48 →	+0.812	+0.536	<.001	.001	3	4
BREAST	DENND1C →	+1.213	+0.335	.002	.005	3	4
BONE	NDUFAF8 →	-1.147	-1.728	.008	<.001	3	4
OVARY	SENP5 →	+0.757	+0.530	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SSH2 by Sympathetic nervous system development activity — LUNG_SCLC

Explore this box plot interactively →