Sympathetic nervous system development

Across TCGA cell cohorts, RNA activity of the Sympathetic nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFOD3, NOC2L, and ARF6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sympathetic nervous system development activity versus OGFOD3 in LUNG_SCLC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OGFOD3 →	+0.721	+1.024	.003	.001	3	3
LUNG_SCLC	NOC2L →	-1.434	-1.575	.004	<.001	3	3
LUNG_NSCLC_LUAD	ARF6 →	+0.603	+0.327	.008	.009	3	2
LUNG_NSCLC_LUAD	NUP62 →	+0.502	+0.232	.009	.006	3	2
LUNG_NSCLC_LUAD	LAMA3 →	+1.465	+0.347	.002	.005	3	2
SKIN	HMOX2 →	-0.602	-1.026	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048485 vs OGFOD3 — LUNG_SCLC

Explore this scatter interactively →