Enteric nervous system development

Across TCGA patient cohorts, RNA activity of the Enteric nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP48, HAP1, and AK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enteric nervous system development activity versus USP48 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	USP48 →	+0.358	+0.214	<.001	<.001	3	5
CCRCC	HAP1 →	-0.061	-0.355	<.001	.003	3	4
PDAC	AK2 →	+0.299	+0.181	.005	.006	3	4
LUAD	ARHGEF10L →	+0.498	+0.382	.001	.001	3	4
LUAD	ADPRS →	+0.298	+0.298	.003	.008	3	3
LUAD	PSMB2 →	+0.285	+0.340	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048484 vs USP48 — BRCA

Explore this scatter interactively →