Enteric nervous system development

Across TCGA cell cohorts, RNA activity of the Enteric nervous system development pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP42, NHP2, and ADCYAP1R1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP42 grouped by Enteric nervous system development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP42 →	+0.323	+1.626	.004	.002	3	2
SKIN	NHP2 →	+0.307	+1.150	<.001	.009	3	2
BREAST	ADCYAP1R1 →	+0.226	+1.833	.008	.001	3	2
LUNG_SCLC	PSMD11 →	-0.199	-1.452	.007	.005	3	2
LUNG_SCLC	HAO2 →	+0.436	+1.880	<.001	<.001	3	2
LUNG_SCLC	MRM2 →	-0.178	-1.736	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP42 by Enteric nervous system development activity — SKIN

Explore this box plot interactively →