Enteric nervous system development

Across TCGA cell cohorts, RNA activity of the Enteric nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC6, PIP4K2A, and BEND6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enteric nervous system development activity versus CCDC6 in SKIN (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCDC6 →	-0.455	-1.654	.001	<.001	3	3
SKIN	PIP4K2A →	-1.278	-1.556	<.001	<.001	3	3
SKIN	BEND6 →	+1.419	+1.558	.004	.002	3	3
BREAST	HIRA →	+0.761	+1.462	.005	.002	2	3
BREAST	UNC5A →	-1.927	-1.847	.004	<.001	3	2
BREAST	FOXK2 →	+1.043	+1.553	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048484 vs CCDC6 — SKIN

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