Autonomic nervous system development

Across TCGA patient cohorts, RNA activity of the Autonomic nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD79B, ARHGAP9, and WAS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autonomic nervous system development activity versus CD79B in CCRCC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CD79B →	-0.363	-0.437	<.001	.008	3	4
HNSC	ARHGAP9 →	-0.881	-0.766	.001	<.001	3	4
HNSC	WAS →	-0.763	-0.648	.003	.007	3	4
BRCA	ANTXRLP1 →	-0.227	-0.516	<.001	.002	3	4
HNSC	PIK3R5 →	-0.774	-0.813	.002	<.001	3	4
HNSC	LINC01934 →	-0.365	-0.487	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048483 vs CD79B — CCRCC

Explore this scatter interactively →