Autonomic nervous system development

Across TCGA cell cohorts, RNA activity of the Autonomic nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NNMT, S100A3, and MRC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NNMT grouped by Autonomic nervous system development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NNMT →	-4.418	-1.030	.001	<.001	3	6
LARGE_INTESTINE	S100A3 →	-1.843	-0.485	<.001	.004	3	5
LIVER	MRC2 →	-3.068	-1.030	<.001	<.001	3	5
LIVER	S100A2 →	-2.175	-0.961	.002	.002	3	5
KIDNEY	C3 →	-3.831	-1.283	.002	<.001	3	4
LARGE_INTESTINE	SERPINE1 →	-1.622	-0.445	.009	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NNMT by Autonomic nervous system development activity — LIVER

Explore this box plot interactively →