Oogenesis

Across TCGA patient cohorts, RNA activity of the Oogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANLN_S485, ATAD2_S342, and SMC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oogenesis activity versus ANLN_S485 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANLN_S485 →	+1.033	+0.022	<.001	<.001	3	6
LUAD	ATAD2_S342 →	+1.107	+0.028	<.001	.003	3	5
GBM	SMC2 →	+0.580	+0.053	<.001	<.001	3	5
BRCA	TACC3_S71 →	+1.026	+0.023	<.001	.001	3	5
BRCA	TK1 →	+0.419	+0.020	.001	<.001	3	5
LUAD	BAZ1B_S349 →	+1.219	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048477 vs ANLN_S485 — BRCA

Explore this scatter interactively →