Oogenesis

Across TCGA cell cohorts, RNA activity of the Oogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF14, DARS1, and ACKR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFRSF14 grouped by Oogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TNFRSF14 →	-0.365	-0.242	.002	.009	3	7
LUNG_NSCLC_LUAD	DARS1 →	+0.338	+0.199	.001	<.001	3	5
LIVER	ACKR1 →	+0.262	+0.205	.009	.004	3	5
BONE	HAT1 →	+0.232	+0.412	.008	.007	3	5
BLOOD_Leukemia	SF3A1 →	+0.295	+0.224	<.001	<.001	3	5
LARGE_INTESTINE	FRMD7 →	-0.128	-0.145	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFRSF14 by Oogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →