Oogenesis

Across TCGA cell cohorts, RNA activity of the Oogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPY2R, CACNA1E, and SOHLH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPY2R grouped by Oogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NPY2R →	-0.223	-1.325	.004	<.001	3	4
LIVER	CACNA1E →	+0.226	+1.809	.002	<.001	3	4
SKIN	SOHLH2 →	-0.169	-0.748	.003	.006	1	6
LARGE_INTESTINE	OLIG3 →	+0.211	+1.054	.004	.001	3	4
SKIN	RAB18 →	+0.158	+0.801	.001	.002	3	3
LARGE_INTESTINE	TFPI2 →	+0.167	+1.300	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPY2R by Oogenesis activity — SKIN

Explore this box plot interactively →