Oogenesis

Across TCGA cell cohorts, RNA activity of the Oogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB2, CEP57, and TMEM39B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oogenesis activity versus DDB2 in LUNG_NSCLC_LUAD (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DDB2 →	-1.032	-0.847	.006	.004	3	4
BREAST	CEP57 →	+0.944	+1.268	.001	<.001	3	4
BREAST	TMEM39B →	+0.743	+0.711	.004	.003	3	4
BREAST	SLC9A6 →	+1.073	+0.884	.004	<.001	3	4
SKIN	TTC39B →	+0.566	+1.147	.005	<.001	3	4
CNS	NOMO3 →	+1.164	+1.005	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048477 vs DDB2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →