Cell maturation

Across TCGA patient cohorts, RNA activity of the Cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETD5, DDX17, and FNBP4, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell maturation activity versus SETD5 in DLBC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	SETD5 →	+1.197	+0.032	<.001	<.001	3	29
DLBC	DDX17 →	+0.741	+0.027	<.001	<.001	3	28
DLBC	FNBP4 →	+1.140	+0.027	<.001	<.001	3	28
DLBC	ATAD2B →	+0.777	+0.026	<.001	<.001	3	28
ESCA	STARD9 →	+0.804	+0.036	<.001	<.001	3	28
DLBC	OTUD3 →	+0.849	+0.032	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048469 vs SETD5 — DLBC

Explore this scatter interactively →