Cell maturation

Across TCGA patient cohorts, RNA activity of the Cell maturation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATF7IP_S113, GAR1, and MAP7D2_S315, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell maturation activity versus ATF7IP_S113 in BRCA (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATF7IP_S113 →	-0.406	-0.013	.002	.004	3	5
LUAD	GAR1 →	-0.259	-0.017	<.001	.001	3	5
GBM	MAP7D2_S315 →	+0.771	+0.019	.001	.005	3	5
OV	ZNF207 →	-0.293	-0.028	<.001	.001	3	5
OV	C1R →	+0.555	+0.025	.003	<.001	3	4
CCRCC	OLFML2B →	+0.623	+0.023	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048469 vs ATF7IP_S113 — BRCA

Explore this scatter interactively →