Cell maturation

Across TCGA patient cohorts, RNA activity of the Cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK, POC1B, and RNASEH2B-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell maturation activity versus AHNAK in LUAD (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AHNAK →	-0.784	-0.600	<.001	.007	3	4
HNSC	POC1B →	+0.385	+0.681	<.001	<.001	3	3
HNSC	RNASEH2B-AS1 →	+0.348	+0.486	.008	.003	3	3
HNSC	TREM2 →	-0.841	-0.462	.003	.005	3	3
LSCC	RNF135 →	-0.380	-0.525	<.001	.005	3	3
OV	TRIM23 →	-0.549	-0.207	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048469 vs AHNAK — LUAD

Explore this scatter interactively →