Cell maturation

Across TCGA cell cohorts, RNA activity of the Cell maturation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OCIAD2, C9orf40, and ZSCAN16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OCIAD2 grouped by Cell maturation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OCIAD2 →	-2.719	-0.166	.007	.006	3	4
BLOOD_Lymphoma	C9orf40 →	-0.892	-0.276	.005	.004	3	4
UPPER_AERODIGESTIVE_TRACT	ZSCAN16 →	-1.474	-0.228	.005	.004	2	4
SKIN	JTB →	-0.633	-0.430	<.001	.006	3	3
SKIN	PKDCC →	-1.589	-0.696	.001	.009	3	3
OESOPHAGUS	TTBK2 →	+1.488	+0.185	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OCIAD2 by Cell maturation activity — STOMACH

Explore this box plot interactively →