Endosomal lumen acidification

Across TCGA patient cohorts, RNA activity of the Endosomal lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHDC1L, ETS1, and SELENOP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosomal lumen acidification activity versus KHDC1L in OV (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KHDC1L →	+0.105	+0.163	.005	<.001	3	5
CCRCC	ETS1 →	-0.341	-0.123	.002	.001	3	4
CCRCC	SELENOP →	-0.617	-0.168	.003	.005	3	4
HNSC	ARHGEF6 →	-0.561	-0.106	<.001	<.001	3	4
LUAD	KLRG1 →	-0.545	-0.161	.004	.004	3	4
PDAC	ZDHHC15 →	-0.363	-0.136	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048388 vs KHDC1L — OV

Explore this scatter interactively →