Endosomal lumen acidification

Across TCGA cell cohorts, RNA activity of the Endosomal lumen acidification pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF490, PKIA, and RAP1GDS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF490 grouped by Endosomal lumen acidification-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF490 →	+0.210	+0.268	<.001	.001	3	4
CNS	PKIA →	-0.314	-0.245	.001	.001	3	3
OESOPHAGUS	RAP1GDS1 →	+0.208	+1.313	.003	.001	3	3
BONE	ACOT13 →	-0.335	-0.112	.005	.006	2	4
LARGE_INTESTINE	DUSP10 →	+0.130	+1.072	.001	<.001	3	3
BLOOD_Lymphoma	ZNF45 →	+0.416	+0.268	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF490 by Endosomal lumen acidification activity — CNS

Explore this box plot interactively →