Endosomal lumen acidification

Across TCGA cell cohorts, RNA activity of the Endosomal lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1B2, ATP6AP1, and TLE6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosomal lumen acidification activity versus ATP6V1B2 in LUNG_SCLC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATP6V1B2 →	+0.838	+0.276	.008	<.001	3	5
PANCREAS	ATP6AP1 →	+0.646	+0.605	.007	.005	3	5
OESOPHAGUS	TLE6 →	+1.495	+1.187	<.001	<.001	3	4
BLOOD_Leukemia	ATP6V0C →	+0.895	+0.672	<.001	.001	3	4
LUNG_NSCLC_LUAD	AGGF1 →	+0.437	+0.989	.009	<.001	3	3
BLOOD_Leukemia	CTSA →	+1.134	+0.672	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048388 vs ATP6V1B2 — LUNG_SCLC

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