Negative regulation of retinoic acid receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of retinoic acid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAQR4, IL1RL2, and HIGD1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of retinoic acid receptor signaling pathway activity versus PAQR4 in STOMACH (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PAQR4 →	-1.011	-0.174	.005	.008	3	5
BREAST	IL1RL2 →	+1.000	+0.140	.009	<.001	3	5
BREAST	HIGD1A →	-0.974	-0.155	.004	.006	3	5
BONE	SLC9B2 →	-1.240	-0.158	.008	.002	3	4
BONE	WDR82 →	-1.281	-0.152	.006	.008	3	4
BONE	POLR1A →	-1.165	-0.146	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048387 vs PAQR4 — STOMACH

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