Positive regulation of retinoic acid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of retinoic acid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBOX5, CFAP44-AS1, and C6orf62, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of retinoic acid receptor signaling pathway activity versus UBOX5 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UBOX5 →	+0.265	+0.687	.005	<.001	3	4
BRCA	CFAP44-AS1 →	+0.143	+0.600	.005	.005	3	4
LSCC	C6orf62 →	+0.387	+0.491	<.001	.005	3	4
CCRCC	HNRNPUL2 →	+0.267	+0.551	<.001	.003	3	4
CCRCC	ALMS1-IT1 →	+0.402	+0.890	<.001	<.001	3	4
CCRCC	NEU3 →	+0.390	+0.711	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048386 vs UBOX5 — BRCA

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