Mesodermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Mesodermal cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB3, ITGB4_S809, and ITGB4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesodermal cell differentiation activity versus LAMB3 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAMB3 →	+1.085	+1.101	<.001	<.001	3	6
PDAC	ITGB4_S809 →	+0.895	+1.342	<.001	<.001	3	6
PDAC	ITGB4 →	+0.611	+1.150	<.001	<.001	3	6
LSCC	ITGB4_T1530 →	+0.941	+1.122	<.001	<.001	3	5
HNSC	LAMC2 →	+1.117	+1.007	<.001	<.001	3	5
PDAC	CDA →	+0.713	+0.922	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048333 vs LAMB3 — LSCC

Explore this scatter interactively →