Mesodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Mesodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, CBX2, and SCML2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesodermal cell differentiation activity versus ITGA3 in SKIN (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ITGA3 →	+2.792	+0.243	<.001	<.001	3	12
LUNG_NSCLC_LUSC	CBX2 →	-1.942	-0.282	<.001	<.001	3	11
LUNG_NSCLC_LUAD	SCML2 →	-0.914	-0.107	<.001	.001	3	10
LUNG_NSCLC_LUSC	WNK2 →	-1.639	-0.198	.004	.004	3	10
LUNG_NSCLC_LUSC	B3GNT3 →	+2.659	+0.230	.009	.009	3	9
LIVER	TDG →	-0.821	-0.234	.006	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048333 vs ITGA3 — SKIN

Explore this scatter interactively →