Mesoderm morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesoderm morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DKK3, CNN2, and COL1A2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesoderm morphogenesis activity versus DKK3 in LSCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DKK3 →	+0.673	+0.036	<.001	.001	3	9
OV	CNN2 →	+0.642	+0.037	.001	<.001	3	8
GBM	COL1A2 →	+0.756	+0.039	.007	.001	3	8
OV	COL3A1 →	+0.720	+0.032	<.001	<.001	3	8
OV	SULF1 →	+0.922	+0.040	<.001	.001	3	8
CCRCC	VCAN →	+1.178	+0.040	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048332 vs DKK3 — LSCC

Explore this scatter interactively →