Mesoderm morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesoderm morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGA2, GJA1, and MCC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesoderm morphogenesis activity versus HMGA2 in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HMGA2 →	+1.668	+1.052	<.001	<.001	3	6
GBM	GJA1 →	+1.153	+0.368	<.001	.002	3	5
LSCC	MCC →	+0.528	+0.638	<.001	<.001	3	5
LSCC	OLFML2A →	+0.630	+0.581	<.001	<.001	3	5
HNSC	AKNA →	-0.635	-0.700	<.001	<.001	3	4
HNSC	POU2AF1 →	-0.925	-0.695	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048332 vs HMGA2 — LSCC

Explore this scatter interactively →