Mesoderm morphogenesis

Across TCGA patient cohorts, RNA activity of the Mesoderm morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN1_S206, ITGB4, and PLEKHG3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesoderm morphogenesis activity versus SEPTIN1_S206 in PDAC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN1_S206 →	-0.667	-0.572	<.001	<.001	3	4
LSCC	ITGB4 →	+0.443	+0.826	<.001	<.001	3	4
LSCC	PLEKHG3 →	+0.329	+0.934	<.001	<.001	3	4
HNSC	PGAM1_S31 →	+0.616	+1.101	<.001	<.001	3	3
PDAC	ASPA →	-0.463	-0.617	<.001	<.001	3	3
PDAC	S100A2 →	+1.398	+0.585	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048332 vs SEPTIN1_S206 — PDAC

Explore this scatter interactively →