Mesoderm morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesoderm morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD8, SPINK6, and USP51, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD8 grouped by Mesoderm morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FZD8 →	-0.288	-1.050	<.001	<.001	3	6
KIDNEY	SPINK6 →	+0.238	+1.203	.004	.009	2	6
PANCREAS	USP51 →	-0.201	-0.512	<.001	.009	3	5
OVARY	SLC25A1 →	-0.232	-0.940	.002	.004	3	4
OVARY	CYP2C9 →	-0.194	-0.751	<.001	<.001	3	4
OVARY	CABP1 →	-0.220	-0.841	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD8 by Mesoderm morphogenesis activity — OVARY

Explore this box plot interactively →