Mesoderm morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesoderm morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCB, RBM4B, and MUTYH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FANCB grouped by Mesoderm morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FANCB →	+0.485	+0.698	.006	.007	2	5
SKIN	RBM4B →	+0.587	+1.003	.001	.002	3	4
LUNG_SCLC	MUTYH →	+0.873	+0.315	<.001	<.001	3	3
LUNG_SCLC	C20orf194 →	+1.226	+0.517	.003	<.001	3	3
BLOOD_Leukemia	TRIM37 →	+0.996	+1.359	.001	.003	2	4
BLOOD_Leukemia	HBS1L →	+1.511	+1.473	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FANCB by Mesoderm morphogenesis activity — STOMACH

Explore this box plot interactively →