Mesoderm morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesoderm morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, ITGA3, and PLAU, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesoderm morphogenesis activity versus ITGA2 in SOFT_TISSUE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ITGA2 →	+4.488	+0.534	<.001	.007	3	11
BONE	ITGA3 →	+4.612	+0.522	.002	.005	3	9
KIDNEY	PLAU →	+5.342	+0.300	.002	.005	3	8
STOMACH	LAMA3 →	+4.209	+0.665	<.001	<.001	3	8
OESOPHAGUS	LAMC2 →	+3.393	+0.526	.001	<.001	3	8
LIVER	ITGB1 →	+1.822	+0.510	.008	.008	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048332 vs ITGA2 — SOFT_TISSUE

Explore this scatter interactively →