Intracellular distribution of mitochondria

Across TCGA patient cohorts, RNA activity of the Intracellular distribution of mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B2, MAP1B, and CLIP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular distribution of mitochondria activity versus ATP8B2 in COAD (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATP8B2 →	-0.536	-0.261	.002	.001	3	5
LSCC	MAP1B →	-0.916	-0.277	<.001	<.001	3	4
PDAC	CLIP3 →	-0.537	-0.216	<.001	<.001	3	4
LSCC	DVL3 →	-0.620	-0.267	.001	.002	3	4
LSCC	HRNR →	-0.767	-0.252	.001	.001	3	4
LUAD	LINC02555 →	+1.014	+0.289	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048312 vs ATP8B2 — COAD

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