Mitochondrion distribution

Across TCGA patient cohorts, RNA activity of the Mitochondrion distribution pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOGA1, LMNB2, and DPF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion distribution activity versus SOGA1 in LSCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOGA1 →	-0.759	-0.336	<.001	.001	3	4
LSCC	LMNB2 →	-0.868	-0.375	<.001	<.001	3	4
CCRCC	DPF1 →	-0.100	-0.441	.003	.005	3	3
CCRCC	SGO1 →	-0.318	-0.621	.004	.002	3	3
CCRCC	MIR616 →	-0.774	-0.680	.004	<.001	3	3
CCRCC	RNU7-4P →	+0.782	+0.377	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048311 vs SOGA1 — LSCC

Explore this scatter interactively →