Mitochondrion distribution

Across TCGA cell cohorts, RNA activity of the Mitochondrion distribution pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QBP, RABEPK, and COPS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion distribution activity versus C1QBP in LARGE_INTESTINE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QBP →	+1.098	+0.965	<.001	.004	3	7
PANCREAS	RABEPK →	+1.280	+1.470	.001	<.001	3	6
BLOOD_Lymphoma	COPS3 →	+0.602	+0.141	.003	.004	3	6
BLOOD_Lymphoma	ATP5F1C →	+0.550	+0.188	.001	.002	3	6
BONE	TMEM127 →	-1.036	-0.453	.005	.006	3	5
BLOOD_Lymphoma	SDHAF3 →	+1.428	+0.139	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048311 vs C1QBP — LARGE_INTESTINE

Explore this scatter interactively →